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ACS Pharmacol Transl Sci

10.3390/ijms23158548 15 DuanX.CaiH.HuT.LinL.ZengL.WangH.et al (2022)

Activation and deactivation of thyroxine need the participation of DIOs to complete ( Figure 1 When iodine is sufficient in the body, the production of H2O2 is the step that limits the synthesis of thyroid hormones

However, the extent to which SLC7A11 dependency defines ferroptosis sensitivity varies substantially across cell types, metabolic states, and microenvironmental nutrient availability