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Dexamethasone, a synthetic glucocorticoid, has been documented to elicit the production of ROS either through direct means or as a consequence of endothelial nitric oxide synthase (eNOS) uncoupling, which is attributed to the constrained availability of tetrahydrofolate (59, 60)

The goal is to keep regain minimal enough that the reset period provides net benefit when medication is restarted with restored sensitivity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 240.Lupertz R

Thymosin alpha-1 enhances immune function, benefitting individuals dealing with chronic infections, autoimmune disorders, or immune suppression