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Metabolism of arginine by the isolated perfused rat kidney
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In ALS, mutated TDP-43 can disrupt nuclear integrity and hamper the nonhomologous end-joining (NHEJ) pathways crucial for repairing double-strand DNA breaks in neurons
In fact its a time bomb and there will be guaranteed casualties amongst B12 deficient patients who only take oral tablets during this period
To test this hypothesis, we designed peptides by substituting negatively charged amino acids and those with a CSP greater than two standard deviations 38 with alanine
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