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29 In this context, GLP-1R agonists represent an intermediate therapeutic option, more effective than lifestyle or other pharmacological approaches, yet less invasive than surgical procedures

Persistent elevation may indicate ongoing oxidative stress or bile duct issues

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Beyond obvious effects on energy balance, dietary quality can also influence obesity risk through changes in metabolic adaptation due to a high refined carbohydrate diet, in resting energy expenditure (such as through brown or beige adipose tissue thermogenesis), in microbiome calorie utilization (with corresponding greater or lesser utilization by the host tissues), and in epigenetic or trans -generational risk of obesity [81,82]