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The relatively high expression of Gsr in BM, spleen, and thymus suggests that Gsr may play an important function in immune defense against pathogens

Contraindications include a personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or a history of pancreatitis

However, while it may have an indirect effect on GLP-1 secretion, the studies are limited, and no large-scale clinical trials have confirmed its impact on weight loss through GLP-1 pathways alone

It just really means it isn't as simole as using it without pred and you might find weight loss rather slower than you might have thought from media reports

Massmig et al., 2020