folate and glutathione Vitamin B12 is the essential cofactor that lets the Cycle hand a methyl group to homocysteine (via methionine synthase), enabling methionine → SAMe production; SAMe is the cell's universal methyl donor Methylation cycle hypothesis - MEpedia

A meta-analysis of three large randomized controlled trials in high-risk subjects did not demonstrate any increase in colorectal adenoma recurrence in subjects supplemented with 500 or 1,000 g/day of folic acid for 24 to 42 months when compared with placebo treatment (134)

Experiment with both forms. Why does methylfolate make me feel restless or wired

Often called the body's "master antioxidant," it sits at the centre of how your cells defend themselves against everyday stress from pollution, sun, processed food, and ageing

Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease 15

Even if each compound looks safe alone, the combination deserves a thoughtful plan