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Three classes of non-insulin antihyperglycemic agents (metformin, GLP-1RA, SGLT2i) can reduce A1C, weight, and insulin dose when added to insulin in type 1 diabetes and were considered for inclusion in this updated guideline

The key distinction lies in the specific chemical structure : only medications containing the sulphonamide functional group (SONH attached to a benzene ring, with arylamine and heterocyclic components) pose a risk

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When used together, they create a synergistic effect that tackles metabolic dysfunction from multiple angles simultaneously