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11 Finally, weight reduction reduces levels of TNF, IL6, and other cytokines secreted by endocrinologic adipose cells and GLP1RAs may have effects on reward pathways and mood that exacerbate psoriasis or its comorbidities (ie, alcohol or substance abuse)

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The SURPASS head-to-head trial (SURMOUNT-5) showed tirzepatide 10mg and 15mg produced significantly greater weight loss than semaglutide 2.4mg, which is the maximum approved semaglutide dose