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These findings suggest that benfotiamines gastroprotective effects are mediated through its antioxidant and anti-inflammatory properties, which help mitigate the tissue damage and inflammatory response associated with indomethacin-induced gastric ulcers

This is distinct from diabetic ketoacidosis (DKA), a dangerous condition that occurs primarily in type 1 diabetes or severe insulin deficiency

While this effect diminishes over time and is unlikely to significantly impact linaclotide (which acts locally), it could affect other oral medications a patient might be taking