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Mol Neurobiol 41(23):129137

Monitor Your Progress Lastly, remember that progress may be slow, and individual results can vary greatly

Typical applications include cell culture experiments assessing telomere dynamics and replicative potential, as well as animal studies monitoring physiological markers and longevity indicators

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DPP-4 Inhibitors Mechanism of action Competitive inhibition of dipeptidyl-peptidase 4 slows degradation of endogenous incretins (GLP-1, GIP) Glucose-dependent insulin secretion Post-prandial glucagon release No direct effect on weight or insulin sensitivity Glycaemic efficacy Advantages Weight-neutral useful when metformin + SU cause weight concern Low hypoglycaemia risk (incretin-dependent action) Oral, generally once-daily