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This can reduce unwanted side effects that have been common with other similar growth hormone stimulators

doi: 10.3389/fpls.2019.01115 Received 14 February 2019 Accepted 14 August 2019 Published 13 September 2019 Volume 10 - 2019 Edited by Dominik K

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This change makes the molecule too hydrophilic to cross BBB, therefore high dose is needed for CNS application [16]