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This effect likely relates to delayed gastric emptying, as high-fat foods naturally slow digestion further, potentially causing discomfort or early satiety

Treatment with MTX (20 mg/kg) caused a 36% reduction in serum albumin compared to the control

World Journal of Hepatology

To induce superovulation, mice were injected intraperitoneally with 10 IU of pregnant mare serum gonadotropin (PMSG), followed 48 hours later by 10 IU of human chorionic gonadotropin (hCG)

It has been shown by the cited studies above that GLP-1R exists on reward pathways, in addition to the amygdala, dorsal raphe, LS, hippocampus, and also BNST