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The amount of urea that enters the proximal tubule from the glomerular filtration apparatus is nearly identical to the concentration in the plasma

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Therefore, studies have investigated how CHAC1 is regulated in tumor cells and their microenvironment: Prostate cancer patients frequently develop resistance to docetaxel, a challenge in which cancer-associated fibroblasts (CAFs) have been shown to play a significant role through exosome-mediated signaling ( In gastric cancer, the RNA demethylase ALKBH5 (Alkylated DNA repair protein alkB homolog 5) removes an m 6 A modification from CHAC1 mRNA, a mark normally associated with transcript stability

Free Radic Biol Med (2018) 117:99109

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