These medications are ideal for adults experiencing obesity or overweight, especially those with weight-related conditions such as high blood pressure, type 2 diabetes, or high cholesterol
This effect can last years for some, even if calorie intake increases, making it hard to avoid weight regain
When combined, these effects may compound, increasing cardiovascular stress
In summary, the NMA supports the clinical effectiveness and safety of tirzepatide relative to liraglutide 3 mg and semaglutide 2.4 mg in weight reduction and other clinical outcomes targeted in the management of obesity and overweight for patients without T2D
While Semaglutide helps control appetite, following a balanced diet is important for optimal results