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The NLRP3 inflammasome is a complex consists of a sensor (NLRP3 protein), an adaptor (apoptosis-associated speck-like protein, ASC), and an effector (caspase-1)

The initial stages of human atherogenesis are characterized by LDL transcytosis and efflux across a compromised endothelium having high permeability, with LDL accumulation in the subendothelium [9]

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