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Tissue damage control is a very important component of host defence mechanisms against infection as this enforces the barrier function of epithelial cells to prevent pathogen access to host tissues and limits the disease severity without interfering with pathogen load.30 The pathophysiology of chronic sinusitis has been proposed to involve a dysfunctional immune response that occurs between the host and environment, locally at the level of mucosa

Each author made a separate contribution to the manuscript's conception, composition, and final revision

Based on KEGG metabolic libraries, metabolic pathways with significant differences in metabolites were identified

Furthermore, metabolic comorbidities such as insulin resistance indirectly enhance urate reabsorption through NHE3-mediated (sodiumhydrogen exchanger 3) tubular alkalinization, creating a mechanistic link between metabolic syndrome and hyperuricemia (Gong et al., 2020

They can help determine the appropriate dosage, monitor for potential interactions with other medications or supplements, and assess the overall effectiveness of the treatment