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When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount

Activation of the SIRT6-AMPK signaling pathway by GLP-1RAs may therefore represent an attractive therapeutic strategy to prevent the development and progression of NAFLD and related cardiovascular diseases by modulating cholesterol metabolism

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These findings elucidate the molecular mechanism by which HIR is formed and provide potential strategies against HIR by targeting sulfenylated or oxidatively activated p-GSK-3