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Tell your health care provider right away if you have nausea, vomiting, or diarrhea that does not go away severe stomach problems

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Rapid weight loss often leads to significant lean mass loss, which can negatively affect metabolism, bone density, and long term strength

That part is still up for debate

[168] [169] In June 2025, the European Medicines Agency recommended that the product information for semaglutide medicines be updated to include non-arteritic anterior ischemic optic neuropathy (NAION) as a very rare side effect, [170] while the World Health Organization concluded that the risk management plan for semaglutide should be revised to include NAION as a potential risk