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Rapid weight loss can sometimes have unintended consequences on vein health, leading to or exacerbating conditions like varicose veins and spider veins

10.1038/nrcardio.2016.183 6

Interleukin 6-mediated endothelial barrier disturbances can be attenuated by blockade of the il6 receptor expressed in brain microvascular endothelial cells

Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity

2024;103(26):e38668