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Pfizer's Phase 2b results, presented at the American Diabetes Association meeting in 2023, showed that danuglipron produced dose-dependent weight loss and HbA1c reductions in patients with type 2 diabetes, though with significant gastrointestinal tolerability challenges at higher doses

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it is not approved for weight loss in healthy adults

This increase in respiratory rate was accompanied by a slight increase in respiratory control ratios (the ratio between state 3 and state 4 oxygen consumption) in IF samples, indicating that it reflects an increment in electron transfer capacity and is not a consequence of increased proton leak