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For instance, a number of variants in the GCL gene have been associated with cystic fibrosis [39], and COPD [40]

Consequently, any skin irritation with basement membrane disruption can deteriorate melasma condition and also induce persistence or recurrence type of the disease (Kwon et al., 2016)

Comorbidities: such as thyroid, kidney, or mood changes that could affect metabolism

Elsevier BV: 486498.e7

For medicinal use, anise doses ranging from 600 mg to 9 grams daily have been proven effective in the treatment of conditions like depression ( Doses of up to 20 grams per day of anise seed powder are considered safe for healthy adults ( Summary Anise is available in powder, extract, oil and seed form