The BBB, which is primarily composed of brain microvascular endothelial cells (BMVECs) in close association with astrocytic endfeet, serves as the principal gateway that stringently controls the entry of iron into the brain parenchyma ( 3+ dissociates from transferrin and is reduced to its ferrous form Fe 2+ prior to its transport into the cytosol via DMT1
When substantive new information or evidence emerges, which might meaningfully alter these clinical points, the four contributing organisations will provide a review and update if necessary
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