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Anal Biochem 241:140142 Zalazar L, Saez Lancellotti TE, Clementi M, Lombardo C, Lamattina L, De Castro R, Forns MW, Cesari A (2012) SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity

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doi: 10.14309/ajg.0000000000000783

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Some users report subtly improved hydration or a slightly less dull texture at this point, though tone change is typically still minimal or not consciously noticeable