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This unpaired cysteine, likely capped by glutathione during production, will require subsequent modification (e.g., alkylation or acetylation) as part of the preclinical and chemistry, manufacturing, and controls (CMC) efforts needed for clinical trials to limit potential oxidation issues

Supplementation has been associated with enrichment of beneficial genera such as Akkermansia muciniphila and Lactobacillus , enhancing SCFA availability

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This effect is thought to be mediated through GLP-1 receptors in the cardiovascular system and is generally not clinically significant, though patients with certain arrhythmias or those sensitive to heart rate changes should be monitored