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Nevertheless, we argue that a cytodegeneration of the myelinating unit may be the most proximal event, which could be potentially driven by a protein misfolding mechanism like most other neurodegenerative disorders

Any excess continues to circulate throughout the body

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In addition, lilly's preclinical paper also reported less conditioned taste avoidance than cagrilintide in a rat model, although that is not the same to a human nausea comparison