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Over the past few decades, there has been a growing interest in understanding the neurobiological underpinnings of glutamatergic dysfunctions in the pathogenesis of depressive disorders and the development of new pharmacological and non-pharmacological treatment options

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For example, we know that many individuals with biological Alzheimer's disease may not develop cognitive symptoms in their lifetime, or not develop symptoms for many years in the future

Amino Acids 42 , 231246 (2012)

and 25 patients received a combination of acetyl-l-carnitine at a dose used in arm A plus low-dose, i.e., 150 mg/day, pregabalin (arm C) for 8 weeks and were subsequently observed for an additional 8 weeks to assess relapse latency and frequency