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Mutations can also occur in the principal Nrf2 repressor, Keap1 or component of the E3 ubiquitin-ligase complex Cullin 3 (CUL3), with loss of function that renders these factors unable to bind Nrf2 and thus result in persistent Nrf2 activation [68]

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence

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Extending the hair growth phase GHK-Cu helps prolong the anagen (growth) phase of the hair cycle, ensuring that hair follicles remain productive for longer periods