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NHS weight-loss drug rule change from Wednesday - 1.2 million more qualify People who are not obese but overweight and at risk of serious cardiovascular events will be eligible for weekly jabs, NHS England is set to offer weight-loss drugs to 1.2 million people to reduce the risk of heart attacks and strokes

Obesity-related metabolomic profiles and discrimination of metabolically unhealthy obesity

The mechanisms behind GLP-1-related headaches are not fully understood, but likely involve changes in blood sugar levels (especially during early treatment when insulin sensitivity improves rapidly), dehydration from reduced fluid intake or GI losses, and the central nervous system effects of GLP-1 receptor activation, since GLP-1 receptors exist in the brain

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The GIP works to enhance the effect of the GLP-1, promoting a more comprehensive approach to managing diabetes and obesity