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GPx4 lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues

The tirzepatide adjustment timeline and the general GLP-1 onset period both illustrate that temporary discomfort often precedes significant benefit

These findings showed that although the duration of treatment could explain some of the heterogeneity, it did not help predict the SMD between arms of studies

However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)

So the chemically castrated patient, meaning they have no testosterone so if you treat a patient who has no testosterone and you take them from zero testosterone to normal testosterone, so to take them from, let's say, zero to 350, um, during that climb from zero to 350, you can increase theoretically, the risk of exasperating a prostate cancer that's pre pre-existing was the fear