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By staying hydrated, you can: help your body metabolize the semaglutide so its as effective as possible help your kidneys filter waste and byproducts of the medication from your blood maintain your energy and prevent dehydration help prevent or ease constipation or digestive distress Side effects of semaglutide weight loss drugs Studies have shown that most people taking semaglutide drugs have mild-to-moderate side effects, mostly around gastrointestinal upset or nausea ( see: Mayo Clinic and Nature)

The rates are remarkably similar across all three, despite their different mechanisms: Semaglutide: Nausea approximately 18%, diarrhea approximately 12%, vomiting approximately 8% Tirzepatide: Nausea 17-22% (dose dependent), diarrhea 13-16%, vomiting 6-10% Retatrutide: Nausea 16-25% (dose dependent), diarrhea 15-22%, vomiting 8-13% The pattern holds consistently

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