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Moreover, GLP-1RA reduced the risk of MACE by 14% in the overall diabetic population, with an apparent greater effect in patients with established CV disease (16% vs 6% reduction, respectively), although the lack of significant interaction between subgroups does not allow to separate them [12]

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Dado que estos frmacos ralentizan significativamente el vaciamiento gstrico, los pacientes frecuentemente experimentan efectos secundarios gastrointestinales, siendo el estreimiento uno de los ms comunes, reportado en hasta aproximadamente 25% de los usuarios con dosis para prdida de peso, segn las etiquetas de prescripcin de la FDA