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For instance, P115 and GRASP65 trigger apoptosis via the ERK/p53/PUMA pathway or Fas-mediated signaling, respectively, whereas Bruce and GAAP decrease apoptosis via caspase-9, Smac and p53 inhibition, and Ca 2+ signaling downregulation [93]

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[11] This reinforces that NAD+ therapy, when administered in a controlled medical setting, has a favorable safety profile