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Description

Retatrutide, because it adds glucagon receptor activation, may cause additional metabolic effects that neither semaglutide nor tirzepatide produce, including greater fat oxidation and potentially different hunger pattern changes

Cicero AFG, Allkanjari O, Busetto GM, et al

BMC Medicine [Internet]

However, like other GLP-1 receptor agonists, it may not be suitable for individuals with a history of thyroid cancer, certain endocrine disorders, or severe gastrointestinal conditions