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The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment

However, these mechanisms warrant further investigation

Patient and caregiver education promotes awareness and empowers them to respond effectively to hypoglycemia, ensuring timely treatment

2022 Feb;179(4):55770

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