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In a clinical trial, TB4 at a dose of 0.03% applied topically to venous ulcers led to complete wound healing in 33.3% of patients, compared to 23.5% for placebo

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In human observational studies, both the AEDG peptide and its parent extract epithalamin were associated with significant telomere length increases in blood cells of subjects aged 6080, with a separate study documenting an 1119% increase in telomere length in subjects aged 6080 receiving the pineal peptide bioregulator (5)