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It typically presents as: Sudden, usually painless loss of vision in one eye A dark or gray shadow in part of the visual field Reduced visual clarity or contrast Visual changes that develop over hours to days, not months NAION is already a leading cause of sudden vision loss in adults over 50

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Although WS neurons from Gadd45a knockout mice might exhibit hyperexcitability under baseline conditions, knockout mice did not show a significant firing-rate alternation when mice switched into the social stage (Fig

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