glp 1 drug mechanism of action GLP1-GIP receptor co-agonists: a promising evolution in the treatment type 2 diabetes | Acta Diabetologica If GLP-1 Drugs Are Good

What the new mechanism is: GLP-1 : appetite regulation, improved glucose control GIP : incretin effects that may augment metabolic benefits Glucagon receptor activity : potentially influences energy expenditure and fat metabolism (while requiring careful balancing of tolerability and metabolic effects) What results look like (so far): Phase 2 (48 weeks) published in NEJM showed substantial mean weight reductions (with higher doses showing very large effects)

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Metabolic-System Uncertainty NNMT participates in nicotinamide and methyl-donor metabolism

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(PubMed) Zeisel SH