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Results SIRT3 suppresses HSC response to classic trained immunity, acute inflammation and tissue functional decline To determine whether SIRT3 regulates HSC response to classic trained immunity induction, we crossed Cre-inducible Sirt3 -overexpressing mice with Mx1-Cre mice to generate mice that overexpress SIRT3 in the hematopoietic system (Mx1-T3) (Extended Data Fig