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[PubMed] [Google Scholar] Pechulis AD, Beck JP, Curry MA, Wolf MA, Harms AE, Xi N, Opalka C, Sweet MP, Yang Z, Vellekoop AS, Klos AM, Crocker PJ, Hassler C, Laws M, Kitchen DB, Smith MA, Olson RE, Liu S, and Molino BF (2012) 4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

If you notice ice crystals in the liquid, or if you accidentally left your medication in a part of the fridge that reached freezing temperatures, do not use it

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As a result, the long-term GI safety of these agents continues to be actively investigated