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Assay: Glutathione in rat tissue

As an example, GSH depletion has been shown to promote pro-inflammatory microglial phenotypes and amplify astrocyte-microglia crosstalk (Vilhardt et al., 2017)

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The synergy in muscle function appears to stem from polyphenols ability to mitigate the negative consequences of exercise (e.g., oxidative stress, inflammation, damage) while simultaneously enhancing the adaptive responses (e.g., mitochondrial biogenesis, anabolism)