After a closed head injury, ApoE / mice exhibit elevated levels of iron in their brains, suggesting that ApoE / deficiency may increase the risk of oxidative damage to hippocampal tissue ( In vitro studies show that upregulating sestrin2 decreases type I/II collagen and KEAP1 mRNA expression while increasing GPX4 and Nrf2 mRNA levels
Publication Bias Positive findings are generally more likely to be published than negative studies
The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial
Procedural factors influencing risk include procedure urgency (emergency versus elective), duration and complexity, requirement for general anaesthesia versus regional techniques, and institutional experience with alternative management strategies [50]
However, patients with diabetes may experience hearing problems due to the underlying condition itself, as diabetes can affect blood vessels and nerves in the inner ear over time