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This slow increase is done to reduce side effects

63%) and most did not have Laron syndrome (n = 238

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Eltokhi A, Santuy A, Merchan-Perez A, Sprengel R

If it senses that thyroid hormone levels are dropping, it releases Thyroid Stimulating Hormone (TSH)

Vinca alkaloids: Although not studied, fluconazole may increase the plasma levels of the vinca alkaloids (e.g., vincristine and vinblastine) and lead to neurotoxicity, which is possibly due to an inhibitory effect on CYP3A4

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