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Should evidence of a concomitant infection emerge, perioperative and long-term management strategies must then be adjusted accordingly

Contraindications Hypersensitivity to the active substance or other components of the drug

The concept of neuronal hyperexcitability has been previously proposed for CVS and has served as a possible link with several other episodic CNS disorders (8688)

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While some mechanisms by which anticancer drugs induce hypertension have been identified, further preclinical and clinical studies are needed to elucidate the exact pathophysiology of hypertension associated with anticancer therapy and to optimize its management [37]