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[DOI] [PubMed] [Google Scholar] 4.McCullough P.A., Steigerwalt S., Tolia K., Chen S.C., Li S., Norris K.C., Whaley-Connell A., KEEP Investigators Cardiovascular disease in chronic kidney disease: Data from the Kidney Early Evaluation Program (KEEP) Curr

5-Amino-1MQ was developed as a pharmacological tool to inhibit NNMT activity, and preclinical studies have demonstrated that oral administration of 5-Amino-1MQ to obese rodents produces dose-dependent reductions in body weight and fat mass, improvements in glucose metabolism and insulin sensitivity, and increases in energy expenditure - remarkably, these effects occur without changes in food intake, indicating that 5-Amino-1MQ works through metabolic enhancement and increased caloric burn rather than appetite suppression

Evidence in humans remains early and limited