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GHS can mildly increase insulin resistance and glycated hemoglobin (HbA1c) levels over time

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Our findings also documented that oral semaglutide was not only effective to reduce further heart failure-related outcomes but was also a safe option in people with diabetes and heart failure, thus refuting prior potential concerns related to safety, Pop-Busui said

Participants received placebo or orforglipron at doses up to 36 mg daily for 72 weeks