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[3] This does not mean the drug "failed." It means obesity is a chronic condition requiring long-term management, a principle stated directly in the Endocrine Society's 2022 pharmacological management guidelines: "Patients should be counseled that pharmacotherapy for obesity is generally required long-term, similar to pharmacotherapy for hypertension or dyslipidemia." [4] Women considering Amble should factor long-term medication costs into their decision, not just the first 6 months

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Image Credit: myskin/Shutterstock.com Background Obesity affects around 650 million adults globally, which has increased the burden of associated comorbidities, resulting in substantial morbidity and mortality

HepG2 ATP7B-KO cells have been generated by nucleofection of a custom-made CompoZr zinc finger nuclease plasmid (Sigma