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Mechanistic model of hormonal contraception

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This "menopause belly" develops because your body's systems shift dramatically: Muscle mass naturally decreases with age, slowing metabolism [1] Declining oestrogen affects how your body stores fat [17] Sleep disruptions and hormonal changes can increase appetite [1] Overall activity levels often decrease [1] Up to 50% of women report weight gain as their most troublesome menopause symptom, with some seeing increases of up to 10kg by menopause [18]

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Clinicians can adjust dose or timing, evaluate underlying causes (hormones, medication interactions, psychological factors), or combine with other therapies

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Although maintaining a high rate of de novo FA synthesis concomitantly to lipid breakdown (i.e., fatty acid -oxidation, FAO) could be biochemically and energetically unproductive, it has been reported that this apparently futile metabolic loop can occur in breast cancer cells that survive tumor regression (Havas et al, 2017)

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