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doi: 10.1074/jbc.M805570200 90 FerrisLKMburuYKMathersARFluhartyERLarreginaATFerrisRLet al

"It just may not work as well as getting full therapeutic doses." Those were the doses deemed most effective in clinical trials for GLP-1 agonists

The cardiovascular outcomes trial reported in the same label randomised 8,801 and 8,803 participants and found a primary composite endpoint of 6.5% versus 8% with placebo, hazard ratio 0.80 (95% CI 0.72 to 0.90)

They also play a significant role in glucose regulation, which can indirectly support overall metabolic health

In addition, peptide polyagonists (i.e., synthetic molecules that combine the amino acid sequences of more than one peptide, thus having the ability to bind to more than one receptor), such as tirzepatide (LY3298176) [a dual GLP-1RA and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist] have also been introduced into the management of metabolic diseases, including T2DM and obesity, and also are under investigation for NAFLD with high expectations [7]