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Systemic inflammation, cellular influx and up-regulation of ovarian VCAM-1 expression in a mouse model of polycystic ovary syndrome (PCOS)

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Structural abnormalities of the BBB in CNS disease When multiple CNS diseases (such as Alzheimer's disease, multiple sclerosis, and stroke) occur, the resulting pathological responses (including inflammation, lipid peroxidation, and excitotoxicity) destabilize the BBB, leading to its dysfunction[38, 39]