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The natural form of GLP-1, which our bodies produce, is short-lived and is quickly broken down by the action of a protein called DPP-4

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Given the candidate ADC's cytotoxic payload demanded extremely high conjugation stability and controlled release, conventional enzyme-cleavable linkers could not meet the dual needs for precise release and plasma stability

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GLP-1 receptor agonist medications are prescription drugs designed to mimic the activity of naturally occurring GLP-1 by binding to GLP-1 receptors throughout the body